The Effect Of 4-Weeks Dutasteride Use On Perioperative Blood Loss In Patients Undergoing Transurethral Resection Of Prostate: Original Article

Junaid Jamil Khattak; Waqar Hassan Shaikh; Liaqat  Ali; Aitzaz Shaikh; Shahzad Ur Rehman

Authors

Junaid Jamil Khattak
Waqar Hassan Shaikh
Liaqat Ali
Aitzaz Shaikh
Shahzad Ur Rehman

Abstract

ABSTRACT:

Background: Among old men, BPH is the most common urological illness. Medicinal and surgical treatments can be used. In medication, both 5-alpha reductase inhibitors and alpha-blockers are used. TURP, or transurethral resection of the prostrate, serves sufferers new to conventional therapy. They are 5-ARI aims to reduce the size and vascularity of the prostate in the meantime. The aim of this study was to investigate whether 5-ARI Dutasteride might reduce blood loss during TURP for BPH by drugs that block 5-ARI.

Objectives :The goal of this research was to see if preTURPitterside, a 5-alpha reeducates inhibitor (5-ARI), can reduce the amount of blood lost during surgery–TURP for benign prostatic hyperplasia (BPH)- in contrast and comparison. The postoperative hemoglobin levels for Dutasteride and non-Dutasteride groups having TURP were compared to determine if Dutasteride can reduce blood loss in TURP.

Study design: This Study is a prospective observational study.

Place and duration of the study: A prospective observational study was conducted from field the Institute of Kidney Diseases to December, 2019 at Hayatabad Medical Complex in Peshawar.

Methodology: A prospective observational study was conducted at the Institute of Kidney Diseases at Hayatabad Medical Complex, Peshawar, from field June to December 2019. Patients with TURP who met the inclusion criteria were divided into two groups according to whether they were taking drugs for BPH. The Dutasteride group took 0.5 mg/day of Dutasteride plus alpha-blocker(s), while the non-dutasteride group took alpha-blocker(s) only. A comparison was made of the difference between preoperative and postoperative haemoglobin levels in individuals taking TURP. A subsequent analysis was carried out using SPSS v23.0 to deduce the data.

Results: Postoperative haemoglobin levels were less likely to fall in those individuals who took Dutasteride for TURP than in the non-dutasteride group ( 0.75 mg/dl ± 0.4 VS where is the proof ? 1.3 mg/dl ± 0.4.）

Conclusion: Our research concludes that there is less haemoglobin decline when 5-ARI dutasteride 0.5 mg/day is used four weeks prior to surgery than when no dutasteride is used.

Keywords: Transurethral resection of the prostate, benign prostatic hyperplasia, 5-alpha reductase inhibitor, Dutasteride.